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  <import namespace="http://xbrl.sec.gov/currency/2017-01-31" schemaLocation="http://xbrl.sec.gov/currency/2017/currency-2017-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/exch/2017-01-31" schemaLocation="http://xbrl.sec.gov/exch/2017/exch-2017-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd"/>
  <import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd"/>
  <element name="AmortizedCostAndFairValueDebtSecuritiesAbstract" id="hstm_AmortizedCostAndFairValueDebtSecuritiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DenominatorAbstract" id="hstm_DenominatorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DescriptionOfContractsWithCustomer" id="hstm_DescriptionOfContractsWithCustomer" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DescriptionOfSalesCommissionPlan" id="hstm_DescriptionOfSalesCommissionPlan" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationAccountsReceivableUnbilled" id="hstm_DisposalGroupIncludingDiscontinuedOperationAccountsReceivableUnbilled" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationAccruedRoyaltiesPayable" id="hstm_DisposalGroupIncludingDiscontinuedOperationAccruedRoyaltiesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationCapitalizedSoftwareDevelopmentNet" id="hstm_DisposalGroupIncludingDiscontinuedOperationCapitalizedSoftwareDevelopmentNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationCostOfRevenuesExcludingDepreciationAndAmortization" id="hstm_DisposalGroupIncludingDiscontinuedOperationCostOfRevenuesExcludingDepreciationAndAmortization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" id="hstm_DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationOtherIntangibleAssetsNet" id="hstm_DisposalGroupIncludingDiscontinuedOperationOtherIntangibleAssetsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationPrepaidRoyaltiesNetOfAmortization" id="hstm_DisposalGroupIncludingDiscontinuedOperationPrepaidRoyaltiesNetOfAmortization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" id="hstm_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" id="hstm_DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="DocumentAndEntityInformationAbstract" id="hstm_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthstreamProviderSolutionsMember" id="hstm_HealthstreamProviderSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="HealthstreamWorkforceSolutionsMember" id="hstm_HealthstreamWorkforceSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncomeTaxesDisclosureLineItems" id="hstm_IncomeTaxesDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="IncomeTaxesDisclosureTable" id="hstm_IncomeTaxesDisclosureTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="InterestCoverageRatioOne" id="hstm_InterestCoverageRatioOne" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LetterOfCreditSubfacilityMember" id="hstm_LetterOfCreditSubfacilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LeverageRatioOne" id="hstm_LeverageRatioOne" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" id="hstm_LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" id="hstm_LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NewAccountingStandardsNotYetAdoptedPolicyTextBlock" id="hstm_NewAccountingStandardsNotYetAdoptedPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NumberOfStockIncentivePlans" id="hstm_NumberOfStockIncentivePlans" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="NumeratorAbstract" id="hstm_NumeratorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="PatientExperienceSolutionsMember" id="hstm_PatientExperienceSolutionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ProductDevelopmentMember" id="hstm_ProductDevelopmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ProfessionalServicesMember" id="hstm_ProfessionalServicesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RecentlyAdoptedAccountingStandardsPolicyPolicyTextBlock" id="hstm_RecentlyAdoptedAccountingStandardsPolicyPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RevenueRecognitionAndSalesCommissionsAbstract" id="hstm_RevenueRecognitionAndSalesCommissionsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RevenueRecognitionAndSalesCommissionsLineItems" id="hstm_RevenueRecognitionAndSalesCommissionsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RevenueRecognitionAndSalesCommissionsTable" id="hstm_RevenueRecognitionAndSalesCommissionsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="RevenueRecognitionAndSalesCommissionsTextBlock" id="hstm_RevenueRecognitionAndSalesCommissionsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="RevenueRemainingPerformanceObligationPercentage" id="hstm_RevenueRemainingPerformanceObligationPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SalesCommissionsAmortizationPeriod" id="hstm_SalesCommissionsAmortizationPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SalesCommissionsAmortizationTermDescription" id="hstm_SalesCommissionsAmortizationTermDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SubscriptionSaasServicesMember" id="hstm_SubscriptionSaasServicesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SunTrustBankMember" id="hstm_SunTrustBankMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SwingLineSubfacilityMember" id="hstm_SwingLineSubfacilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="TermOfContractsWithCustomer" id="hstm_TermOfContractsWithCustomer" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>
