<?xml version="1.0" encoding="us-ascii"?>
<!-- DFS ActiveDisclosure(SM) XBRL Schema Document - http://www.dfsco.com/financial-services/ -->
<!-- Creation Date      : 2019-02-25T18:11:06.6173937+00:00 -->
<!-- Version            : 3.3.6989.14284 -->
<!-- Package ID         : cb7e12ab1a0a471aa443d4051341b7a0 -->
<!-- Copyright (c) 2019 Donnelley Financial, LLC. All Rights Reserved. -->
<schema xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:us-types="http://fasb.org/us-types/2018-01-31" xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31" xmlns:srt-types="http://fasb.org/srt-types/2018-01-31" xmlns:naics="http://xbrl.sec.gov/naics/2017-01-31" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:hstm="http://www.healthstream.com/20181231" xmlns:srt="http://fasb.org/srt/2018-01-31" xmlns:us-gaap="http://fasb.org/us-gaap/2018-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2018-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:country="http://xbrl.sec.gov/country/2017-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:currency="http://xbrl.sec.gov/currency/2017-01-31" xmlns:exch="http://xbrl.sec.gov/exch/2018-01-31" xmlns:sic="http://xbrl.sec.gov/sic/2011-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.healthstream.com/20181231" xmlns="http://www.w3.org/2001/XMLSchema">
  <import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
  <import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase" />
  <import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <import schemaLocation="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd" namespace="http://xbrl.sec.gov/dei/2018-01-31" />
  <import schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd" namespace="http://fasb.org/us-gaap/2018-01-31" />
  <import schemaLocation="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd" namespace="http://fasb.org/srt/2018-01-31" />
  <import schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-types-2018-01-31.xsd" namespace="http://fasb.org/us-types/2018-01-31" />
  <import schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/numeric" />
  <import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
  <import schemaLocation="http://xbrl.fasb.org/srt/2018/elts/srt-types-2018-01-31.xsd" namespace="http://fasb.org/srt-types/2018-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd" namespace="http://xbrl.sec.gov/country/2017-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/currency/2017/currency-2017-01-31.xsd" namespace="http://xbrl.sec.gov/currency/2017-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/exch/2018/exch-2018-01-31.xsd" namespace="http://xbrl.sec.gov/exch/2018-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" namespace="http://xbrl.sec.gov/invest/2013-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd" namespace="http://xbrl.sec.gov/naics/2017-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" namespace="http://xbrl.sec.gov/sic/2011-01-31" />
  <import schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" namespace="http://xbrl.sec.gov/stpr/2018-01-31" />
  <annotation>
    <appinfo>
      <link:roleType id="TemplateLink" roleURI="http://www.healthstream.com/20181231/role/TemplateLink" xmlns:link="http://www.xbrl.org/2003/linkbase">
        <link:definition>00000 - Document - Template Link</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="hstm-20181231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:title="Calculation Links, all" xlink:type="simple" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="hstm-20181231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="hstm-20181231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="hstm-20181231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation Links, all" xlink:type="simple" />
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DocumentDocumentAndEntityInformation" id="Role_DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedBalanceSheets" id="Role_StatementConsolidatedBalanceSheets">
        <link:definition>100010 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedBalanceSheetsParenthetical" id="Role_StatementConsolidatedBalanceSheetsParenthetical">
        <link:definition>100020 - Statement - Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedStatementsOfIncome" id="Role_StatementConsolidatedStatementsOfIncome">
        <link:definition>100030 - Statement - Consolidated Statements of Income</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedStatementsOfComprehensiveIncome" id="Role_StatementConsolidatedStatementsOfComprehensiveIncome">
        <link:definition>100040 - Statement - Consolidated Statements of Comprehensive Income</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedStatementsOfShareholdersEquity" id="Role_StatementConsolidatedStatementsOfShareholdersEquity">
        <link:definition>100050 - Statement - Consolidated Statements of Shareholders&apos; Equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedStatementsOfShareholdersEquityParenthetical" id="Role_StatementConsolidatedStatementsOfShareholdersEquityParenthetical">
        <link:definition>100060 - Statement - Consolidated Statements of Shareholders&apos; Equity (Parenthetical)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/StatementConsolidatedStatementsOfCashFlows" id="Role_StatementConsolidatedStatementsOfCashFlows">
        <link:definition>100070 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPolicies" id="Role_DisclosureSummaryOfSignificantAccountingPolicies">
        <link:definition>100080 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockholdersEquity" id="Role_DisclosureStockholdersEquity">
        <link:definition>100090 - Disclosure - Stockholders&apos; Equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEarningsPerShare" id="Role_DisclosureEarningsPerShare">
        <link:definition>100100 - Disclosure - Earnings Per Share</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureMarketableSecurities" id="Role_DisclosureMarketableSecurities">
        <link:definition>100110 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissions" id="Role_DisclosureRevenueRecognitionAndSalesCommissions">
        <link:definition>100120 - Disclosure - Revenue Recognition And Sales Commissions</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosurePropertyAndEquipment" id="Role_DisclosurePropertyAndEquipment">
        <link:definition>100130 - Disclosure - Property and Equipment</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssets" id="Role_DisclosureGoodwillAndIntangibleAssets">
        <link:definition>100140 - Disclosure - Goodwill and Intangible Assets</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDiscontinuedOperations" id="Role_DisclosureDiscontinuedOperations">
        <link:definition>100150 - Disclosure - Discontinued Operations</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureBusinessSegments" id="Role_DisclosureBusinessSegments">
        <link:definition>100160 - Disclosure - Business Segments</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxes" id="Role_DisclosureIncomeTaxes">
        <link:definition>100170 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensation" id="Role_DisclosureStockBasedCompensation">
        <link:definition>100180 - Disclosure - Stock Based Compensation</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEmployeeBenefitPlan" id="Role_DisclosureEmployeeBenefitPlan">
        <link:definition>100190 - Disclosure - Employee Benefit Plan</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDebt" id="Role_DisclosureDebt">
        <link:definition>100200 - Disclosure - Debt</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureLeases" id="Role_DisclosureLeases">
        <link:definition>100210 - Disclosure - Leases</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureCollaborativeArrangement" id="Role_DisclosureCollaborativeArrangement">
        <link:definition>100220 - Disclosure - Collaborative Arrangement</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureLitigation" id="Role_DisclosureLitigation">
        <link:definition>100230 - Disclosure - Litigation</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureNonMarketableEquityInvestments" id="Role_DisclosureNonMarketableEquityInvestments">
        <link:definition>100240 - Disclosure - Non-Marketable Equity Investments</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSubsequentEvents" id="Role_DisclosureSubsequentEvents">
        <link:definition>100250 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" id="Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies">
        <link:definition>100260 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" id="Role_DisclosureSummaryOfSignificantAccountingPoliciesTables">
        <link:definition>100270 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEarningsPerShareTables" id="Role_DisclosureEarningsPerShareTables">
        <link:definition>100280 - Disclosure - Earnings Per Share (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureMarketableSecuritiesTables" id="Role_DisclosureMarketableSecuritiesTables">
        <link:definition>100290 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsTables" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsTables">
        <link:definition>100300 - Disclosure - Revenue Recognition And Sales Commissions (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosurePropertyAndEquipmentTables" id="Role_DisclosurePropertyAndEquipmentTables">
        <link:definition>100310 - Disclosure - Property and Equipment (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssetsTables" id="Role_DisclosureGoodwillAndIntangibleAssetsTables">
        <link:definition>100320 - Disclosure - Goodwill and Intangible Assets (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDiscontinuedOperationsTables" id="Role_DisclosureDiscontinuedOperationsTables">
        <link:definition>100330 - Disclosure - Discontinued Operations (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureBusinessSegmentsTables" id="Role_DisclosureBusinessSegmentsTables">
        <link:definition>100340 - Disclosure - Business Segments (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesTables" id="Role_DisclosureIncomeTaxesTables">
        <link:definition>100350 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationTables" id="Role_DisclosureStockBasedCompensationTables">
        <link:definition>100360 - Disclosure - Stock Based Compensation (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureLeasesTables" id="Role_DisclosureLeasesTables">
        <link:definition>100370 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail" id="Role_DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail">
        <link:definition>100380 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesChangesInAllowanceForDoubtfulAccountsAndAmountsChargedToBadDebtExpenseDetail" id="Role_DisclosureSummaryOfSignificantAccountingPoliciesChangesInAllowanceForDoubtfulAccountsAndAmountsChargedToBadDebtExpenseDetail">
        <link:definition>100390 - Disclosure - Summary of Significant Accounting Policies - Changes in the Allowance for Doubtful Accounts and the Amounts Charged to Bad Debt Expense (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesEstimatedUsefulLivesOfPropertyAndEquipmentDetail" id="Role_DisclosureSummaryOfSignificantAccountingPoliciesEstimatedUsefulLivesOfPropertyAndEquipmentDetail">
        <link:definition>100400 - Disclosure - Summary of Significant Accounting Policies - Estimated Useful Lives of Property and Equipment (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureShareholdersEquityAdditionalInformationDetail" id="Role_DisclosureShareholdersEquityAdditionalInformationDetail">
        <link:definition>100410 - Disclosure - Shareholders Equity - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEarningsPerShareComputationOfBasicAndDilutedEarningsPerShareDetail" id="Role_DisclosureEarningsPerShareComputationOfBasicAndDilutedEarningsPerShareDetail">
        <link:definition>100420 - Disclosure - Earnings Per Share - Computation of Basic and Diluted Earnings Per Share (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEarningsPerShareAdditionalInformationDetail" id="Role_DisclosureEarningsPerShareAdditionalInformationDetail">
        <link:definition>100430 - Disclosure - Earnings Per Share - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureMarketableSecuritiesFairValueOfAvailableForSaleMarketableSecuritiesDetail" id="Role_DisclosureMarketableSecuritiesFairValueOfAvailableForSaleMarketableSecuritiesDetail">
        <link:definition>100440 - Disclosure - Marketable Securities - Fair Value of Available for Sale Marketable Securities (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfCumulativeEffectForAdoptionOfASC606Detail" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfCumulativeEffectForAdoptionOfASC606Detail">
        <link:definition>100450 - Disclosure - Revenue Recognition and Sales Commissions - Schedule of Cumulative Effect for the Adoption of ASC 606 (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfImpactOfAdoptingOfASC606OnCondensedConsolidatedBalanceSheetDetail" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfImpactOfAdoptingOfASC606OnCondensedConsolidatedBalanceSheetDetail">
        <link:definition>100460 - Disclosure - Revenue Recognition and Sales Commissions - Schedule of Impact of Adopting of ASC 606 on Condensed Consolidated Balance Sheet (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfImpactOfAdoptingOfASC606OnCondensedConsolidatedStatementsOfIncomeDetail" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfImpactOfAdoptingOfASC606OnCondensedConsolidatedStatementsOfIncomeDetail">
        <link:definition>100470 - Disclosure - Revenue Recognition and Sales Commissions - Schedule of Impact of Adopting of ASC 606 on Condensed Consolidated Statements of Income (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfRevenuesIncludedInContinuingOperationsDisaggregatedByRevenueSourceDetail" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsScheduleOfRevenuesIncludedInContinuingOperationsDisaggregatedByRevenueSourceDetail">
        <link:definition>100480 - Disclosure - Revenue Recognition and Sales Commissions - Schedule of Revenues Included in Continuing Operations Disaggregated by Revenue Source (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail">
        <link:definition>100490 - Disclosure - Revenue Recognition and Sales Commissions - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail1" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail1">
        <link:definition>100500 - Disclosure - Revenue Recognition and Sales Commissions - Additional Information (Detail 1)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail1Default" id="Role_DisclosureRevenueRecognitionAndSalesCommissionsAdditionalInformationDetail1Default">
        <link:definition>100500 - Disclosure - Revenue Recognition and Sales Commissions - Additional Information (Detail 1)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosurePropertyAndEquipmentSummaryOfPropertyAndEquipmentDetail" id="Role_DisclosurePropertyAndEquipmentSummaryOfPropertyAndEquipmentDetail">
        <link:definition>100510 - Disclosure - Property and Equipment - Summary of Property and Equipment (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosurePropertyAndEquipmentAdditionalInformationDetail" id="Role_DisclosurePropertyAndEquipmentAdditionalInformationDetail">
        <link:definition>100520 - Disclosure - Property and Equipment - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssetsChangesInCarryingAmountOfGoodwillDetail" id="Role_DisclosureGoodwillAndIntangibleAssetsChangesInCarryingAmountOfGoodwillDetail">
        <link:definition>100530 - Disclosure - Goodwill and Intangible Assets - Changes in Carrying Amount of Goodwill (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssetsAdditionalInformationDetail" id="Role_DisclosureGoodwillAndIntangibleAssetsAdditionalInformationDetail">
        <link:definition>100540 - Disclosure - Goodwill and Intangible Assets - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssetsIdentifiableIntangibleAssetsDetail" id="Role_DisclosureGoodwillAndIntangibleAssetsIdentifiableIntangibleAssetsDetail">
        <link:definition>100550 - Disclosure - Goodwill and Intangible Assets - Identifiable Intangible Assets (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureGoodwillAndIntangibleAssetsExpectedAnnualAmortizationExpenseDetail" id="Role_DisclosureGoodwillAndIntangibleAssetsExpectedAnnualAmortizationExpenseDetail">
        <link:definition>100560 - Disclosure - Goodwill and Intangible Assets - Expected Annual Amortization Expense (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDiscontinuedOperationsAdditionalInformationDetail" id="Role_DisclosureDiscontinuedOperationsAdditionalInformationDetail">
        <link:definition>100570 - Disclosure - Discontinued Operations - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDiscontinuedOperationsScheduleOfDiscontinuedOperationsIncomeStatementDetail" id="Role_DisclosureDiscontinuedOperationsScheduleOfDiscontinuedOperationsIncomeStatementDetail">
        <link:definition>100580 - Disclosure - Discontinued Operations - Schedule of Discontinued Operations Income Statement (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDiscontinuedOperationsScheduleOfDiscontinuedOperationsBalanceSheetDetail" id="Role_DisclosureDiscontinuedOperationsScheduleOfDiscontinuedOperationsBalanceSheetDetail">
        <link:definition>100590 - Disclosure - Discontinued Operations - Schedule of Discontinued Operations Balance Sheet (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureBusinessSegmentsBusinessSegmentInformationBasedOnNetRevenuesAndOperatingIncomeDetail" id="Role_DisclosureBusinessSegmentsBusinessSegmentInformationBasedOnNetRevenuesAndOperatingIncomeDetail">
        <link:definition>100600 - Disclosure - Business Segments - Business Segment Information Based on Net Revenues and Operating Income (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureBusinessSegmentsBusinessSegmentInformationBasedOnAssetsDetail" id="Role_DisclosureBusinessSegmentsBusinessSegmentInformationBasedOnAssetsDetail">
        <link:definition>100610 - Disclosure - Business Segments - Business Segment Information Based on Assets (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesSummaryOfProvisionBenefitForIncomeTaxesDetail" id="Role_DisclosureIncomeTaxesSummaryOfProvisionBenefitForIncomeTaxesDetail">
        <link:definition>100620 - Disclosure - Income Taxes - Summary of Provision (Benefit) for Income Taxes (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesReconciliationOfIncomeTaxesAtStatutoryFederalIncomeTaxRateToProvisionForIncomeTaxesDetail" id="Role_DisclosureIncomeTaxesReconciliationOfIncomeTaxesAtStatutoryFederalIncomeTaxRateToProvisionForIncomeTaxesDetail">
        <link:definition>100630 - Disclosure - Income Taxes - Reconciliation of Income Taxes at the Statutory Federal Income Tax Rate to the Provision for Income Taxes (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesAdditionalInformationDetail" id="Role_DisclosureIncomeTaxesAdditionalInformationDetail">
        <link:definition>100640 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesReconciliationOfBeginningAndEndingLiabilityForGrossUnrecognizedTaxBenefitsDetail" id="Role_DisclosureIncomeTaxesReconciliationOfBeginningAndEndingLiabilityForGrossUnrecognizedTaxBenefitsDetail">
        <link:definition>100650 - Disclosure - Income Taxes - Reconciliation of the Beginning and Ending Liability for Gross Unrecognized Tax Benefits (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureIncomeTaxesSignificantComponentsOfDeferredTaxAssetsAndDeferredTaxLiabilitiesDetail" id="Role_DisclosureIncomeTaxesSignificantComponentsOfDeferredTaxAssetsAndDeferredTaxLiabilitiesDetail">
        <link:definition>100660 - Disclosure - Income Taxes - Significant Components of Deferred Tax Assets and Deferred Tax Liabilities (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationAdditionalInformationDetail" id="Role_DisclosureStockBasedCompensationAdditionalInformationDetail">
        <link:definition>100670 - Disclosure - Stock Based Compensation - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationSummaryOfActivityAndVariousOtherInformationRelativeToStockOptionsDetail" id="Role_DisclosureStockBasedCompensationSummaryOfActivityAndVariousOtherInformationRelativeToStockOptionsDetail">
        <link:definition>100680 - Disclosure - Stock Based Compensation - Summary of Activity and Various Other Information Relative to Stock Options (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationOtherInformationRelativeToOptionActivityDetail" id="Role_DisclosureStockBasedCompensationOtherInformationRelativeToOptionActivityDetail">
        <link:definition>100690 - Disclosure - Stock Based Compensation - Other Information Relative to Option Activity (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationSummaryOfActivityRelativeToRSUSDetail" id="Role_DisclosureStockBasedCompensationSummaryOfActivityRelativeToRSUSDetail">
        <link:definition>100700 - Disclosure - Stock Based Compensation - Summary of Activity Relative to RSU&apos;s (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureStockBasedCompensationStockBasedCompensationExpenseRecordedInConsolidatedStatementsOfIncomeDetail" id="Role_DisclosureStockBasedCompensationStockBasedCompensationExpenseRecordedInConsolidatedStatementsOfIncomeDetail">
        <link:definition>100710 - Disclosure - Stock Based Compensation - Stock Based Compensation Expense Recorded in Consolidated Statements of Income (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureEmployeeBenefitPlanAdditionalInformationDetail" id="Role_DisclosureEmployeeBenefitPlanAdditionalInformationDetail">
        <link:definition>100720 - Disclosure - Employee Benefit Plan - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureDebtAdditionalInformationDetail" id="Role_DisclosureDebtAdditionalInformationDetail">
        <link:definition>100730 - Disclosure - Debt - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureLeasesAdditionalInformationDetail" id="Role_DisclosureLeasesAdditionalInformationDetail">
        <link:definition>100740 - Disclosure - Leases - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureLeasesFutureRentalPaymentCommitmentsUnderNonCancelableOperatingLeasesDetail" id="Role_DisclosureLeasesFutureRentalPaymentCommitmentsUnderNonCancelableOperatingLeasesDetail">
        <link:definition>100750 - Disclosure - Leases - Future Rental Payment Commitments under Non-Cancelable Operating Leases (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureCollaborativeArrangementAdditionalInformationDetail" id="Role_DisclosureCollaborativeArrangementAdditionalInformationDetail">
        <link:definition>100760 - Disclosure - Collaborative Arrangement - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureNonMarketableEquityInvestmentsAdditionalInformationDetail" id="Role_DisclosureNonMarketableEquityInvestmentsAdditionalInformationDetail">
        <link:definition>100770 - Disclosure - Non-Marketable Equity Investments - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.healthstream.com/20181231/taxonomy/role/DisclosureSubsequentEventsAdditionalInformationDetail" id="Role_DisclosureSubsequentEventsAdditionalInformationDetail">
        <link:definition>100780 - Disclosure - Subsequent Events - Additional Information (Detail)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </appinfo>
  </annotation>
  <element id="hstm_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxLiabilityProvisionalIncomeTaxBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxLiabilityProvisionalIncomeTaxBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_ContractWithCustomerAssetSalesCommissionNoncurrent" name="ContractWithCustomerAssetSalesCommissionNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_ChangeInFairValueOfCostMethodInvestments" name="ChangeInFairValueOfCostMethodInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_IncreaseDecreaseInDeferredCommissions" name="IncreaseDecreaseInDeferredCommissions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_PaymentsToAcquireCostMethodInvestments" name="PaymentsToAcquireCostMethodInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_NonCashAdditionsToPropertyAndEquipment" name="NonCashAdditionsToPropertyAndEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_NonMarketableEquityInvestmentsDisclosureTextBlock" name="NonMarketableEquityInvestmentsDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_RecentlyAdoptedAccountingStandardsPolicyPolicyTextBlock" name="RecentlyAdoptedAccountingStandardsPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_RevenueFromContractWithCustomerCommissionsPolicyTextBlock" name="RevenueFromContractWithCustomerCommissionsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_NonMarketableEquityInvestmentsPolicyTextBlock" name="NonMarketableEquityInvestmentsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_ShippingAndHandlingCostsPolicyPolicyTextBlock" name="ShippingAndHandlingCostsPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_PropertyPlantAndEquipmentUsefulLivesTableTextBlock" name="PropertyPlantAndEquipmentUsefulLivesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_ScheduleOfShareBasedCompensationAdditionalStockOptionsActivityTableTextBlock" name="ScheduleOfShareBasedCompensationAdditionalStockOptionsActivityTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_BusinessAndBasisOfPresentationLineItems" name="BusinessAndBasisOfPresentationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_BusinessAndBasisOfPresentationTable" name="BusinessAndBasisOfPresentationTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_PatientExperienceSolutionsMember" name="PatientExperienceSolutionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_NewCorporateHeadquartersMember" name="NewCorporateHeadquartersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DeferredCommissionsAmortizationPeriod" name="DeferredCommissionsAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_AdvanceRoyaltyAmortizationPeriod" name="AdvanceRoyaltyAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_CapitalizedSoftwareDevelopmentAmortizationPeriod" name="CapitalizedSoftwareDevelopmentAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_NumberOfPossibleSourcesOfTaxableIncome" name="NumberOfPossibleSourcesOfTaxableIncome" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_NumberOfStockBasedCompensationPlans" name="NumberOfStockBasedCompensationPlans" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_NumeratorAbstract" name="NumeratorAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DenominatorAbstract" name="DenominatorAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_AmortizedCostAndFairValueDebtSecuritiesAbstract" name="AmortizedCostAndFairValueDebtSecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_SubscriptionSaasServicesMember" name="SubscriptionSaasServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_ProfessionalServicesMember" name="ProfessionalServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_HealthstreamWorkforceSolutionsMember" name="HealthstreamWorkforceSolutionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_HealthstreamProviderSolutionsMember" name="HealthstreamProviderSolutionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DescriptionOfContractsWithCustomer" name="DescriptionOfContractsWithCustomer" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_TermOfContractsWithCustomer" name="TermOfContractsWithCustomer" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_RevenueRecognitionAndSalesCommissionsAbstract" name="RevenueRecognitionAndSalesCommissionsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_RevenueRecognitionAndSalesCommissionsLineItems" name="RevenueRecognitionAndSalesCommissionsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_RevenueRecognitionAndSalesCommissionsTable" name="RevenueRecognitionAndSalesCommissionsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DescriptionOfSalesCommissionPlan" name="DescriptionOfSalesCommissionPlan" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_SalesCommissionsAmortizationTermDescription" name="SalesCommissionsAmortizationTermDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_SalesCommissionsAmortizationPeriod" name="SalesCommissionsAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_MorriseyAssociatesIncMember" name="MorriseyAssociatesIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationCostOfRevenuesExcludingDepreciationAndAmortization" name="DisposalGroupIncludingDiscontinuedOperationCostOfRevenuesExcludingDepreciationAndAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" name="DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" name="DisposalGroupIncludingDiscontinuedOperationSellingAndMarketingExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" name="DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationAccountsReceivableUnbilled" name="DisposalGroupIncludingDiscontinuedOperationAccountsReceivableUnbilled" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationPrepaidRoyaltiesNetOfAmortization" name="DisposalGroupIncludingDiscontinuedOperationPrepaidRoyaltiesNetOfAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationCapitalizedSoftwareDevelopmentNet" name="DisposalGroupIncludingDiscontinuedOperationCapitalizedSoftwareDevelopmentNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationOtherIntangibleAssetsNet" name="DisposalGroupIncludingDiscontinuedOperationOtherIntangibleAssetsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_DisposalGroupIncludingDiscontinuedOperationAccruedRoyaltiesPayable" name="DisposalGroupIncludingDiscontinuedOperationAccruedRoyaltiesPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_IncomeTaxesDisclosureLineItems" name="IncomeTaxesDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_IncomeTaxesDisclosureTable" name="IncomeTaxesDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_DeferredTaxLiabilitiesDepreciation" name="DeferredTaxLiabilitiesDepreciation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_StockOptionsAndRestrictedStockUnitsMember" name="StockOptionsAndRestrictedStockUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_ProductDevelopmentMember" name="ProductDevelopmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_EmployeesMinimumAgeEligibilityToParticipateInPlan" name="EmployeesMinimumAgeEligibilityToParticipateInPlan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_MinimumPeriodRequiredToBeEligibleForParticipationInPlan" name="MinimumPeriodRequiredToBeEligibleForParticipationInPlan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_ScheduleOfSaleOfSubsidiaryAbstract" name="ScheduleOfSaleOfSubsidiaryAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_SunTrustBankMember" name="SunTrustBankMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_SwingLineSubfacilityMember" name="SwingLineSubfacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_LetterOfCreditSubfacilityMember" name="LetterOfCreditSubfacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="hstm_LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" name="LineOfCreditFacilityIncreasedFacilitySizeDueToAccordionFeature" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="hstm_LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" name="LineOfCreditFacilityPercentageOfApplicableMarginForBorrowings" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="hstm_LeverageRatioOne" name="LeverageRatioOne" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="hstm_InterestCoverageRatioOne" name="InterestCoverageRatioOne" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="hstm_ExpensesRelatedToCollaborativeArrangement" name="ExpensesRelatedToCollaborativeArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="hstm_CollaborativeArrangementProfitSharePercentage" name="CollaborativeArrangementProfitSharePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="hstm_ProvidigmnLLCMember" name="ProvidigmnLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</schema>
